Humoral Immune Responses and Hepatitis B Infection

نویسندگان

چکیده

<b><i>Background:</i></b> Chronicity or seroclearance of hepatitis B virus (HBV) antigens is determined by the host immune responses. Current approaches to treat HBV patients are based on inhibition replication using different antivirals (nucleoside nucleotide analogs) as monotherapy, along with modulators combination therapy being used worldwide for reducing viral load. Understanding role cellular therapies currently available treatments persistent viral-mediated responses in unexplored. However, generation antibodies against a surface (HBs) and envelop (HBe) antigen remains an issue future studies needs be explored. <b><i>Summary:</i></b> Humoral immunity, specifically T follicular helper (TFh) cells, may serve target HBsAg seroconversion. In this review, we have been engrossed importance humoral CHBV infection vertical transmission. <b><i>Key Message:</i></b> TFh cells suggested potential immunotherapy which lead seroconversion HBe HBs HBV. eradication covalently closed circular DNA main challenges existing forthcoming infection.

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ژورنال

عنوان ژورنال: Digestive Diseases

سال: 2021

ISSN: ['0257-2753', '1421-9875']

DOI: https://doi.org/10.1159/000514274